BRAF mutations in non-small cell lung cancer: has finally Janus opened the door?
نویسندگان
چکیده
منابع مشابه
BRAF-mutations in non-small cell lung cancer.
OBJECTIVES Targeted therapies in non-small cell lung cancer (NSCLC) now also include inhibitors against mutated BRAF. We present clinicopathological characteristics of nearly one thousand unselected NSCLC patients tested for the targetable V600E/K BRAF-mutation. MATERIAL AND METHODS NSCLC routinely tested for EGFR-mutations at Oslo University Hospital in the period February 2011-July 2013 wer...
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Epidemiological studies have demonstrated a strong association between tobacco use and lung cancer; however, the genetic targets of these carcinogens and the role of other environmental agents in this process have yet to be defined. We examined the contribution of alcohol use and cigarette smoking to p53 gene mutations in patients with non-small cell lung cancer. Mutations of the p53 gene were ...
متن کاملClinical significance of BRAF gene mutations in patients with non-small cell lung cancer.
BACKGROUND V-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations are attractive molecular targets for cancer treatment. Detection of BRAF gene mutation and analyses in non-small cell lung cancer (NSCLC) are of great scientific interest. PATIENTS AND METHODS The study included 581 NSCLC patients (377 males, 204 female) undergoing pulmonary resection. BRAF gene mutations were screened...
متن کاملClinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
PURPOSE BRAF mutations are found in a subset of non-small cell lung cancers (NSCLC). We examined the clinical characteristics and treatment outcomes of patients with NSCLC harboring BRAF mutations. EXPERIMENTAL DESIGN Using DNA sequencing, we successfully screened 883 patients with NSCLC for BRAF mutations between July 1, 2009 and July 16, 2012. Baseline characteristics and treatment outcomes...
متن کاملBRAF Mutations in Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
BACKGROUND BRAF mutations have been well described in non-small cell lung cancer (NSCLC) for several years, but the clinical features of patients harboring BRAF mutations are still not well described. We performed a meta-analysis to identify common clinical features in NSCLC patients carrying BRAF mutations. METHODS We identified clinical studies that examined the association between BRAF mut...
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ژورنال
عنوان ژورنال: Critical Reviews in Oncology/Hematology
سال: 2016
ISSN: 1040-8428
DOI: 10.1016/j.critrevonc.2016.02.012